Lung Microbiome Intervention Attenuates Herpesvirus-Induced Post-HCT Pulmonary Fibrosis Through PD-L1 Upregulation on Dendritic Cells
Joshua B. Perkins, Keerthikka Ravi, Chunfang Guo, Gina J. Oh, Bellmary G. Rodriguez, Stephen J. Gurczynski, Jason B. Weinberg, Gary B. Huffnagle, David N. O’Dwyer, Bethany B. Moore, Xiaofeng Zhou
This study shows that heat-killed Lactobacillus johnsonii reduces herpesvirus-induced pulmonary fibrosis in HCT mice by increasing PD-L1 on dendritic cells, which suppresses Th17 cell IL-17A.
bioRxiv · Jul 6, 2024 · PreprintImmunology