Stephen J. Gurczynski

Cell-Specific Modulation of the Aryl Hydrocarbon Receptor by Kynurenine in Pulmonary Fibrosis Requires Microenvironmental Crosstalk

This study shows that kynurenine modulates AHR signaling in specific pulmonary cell types, with pathogenic effects requiring cell-cell interactions, not isolated cell responses.

Toxoplasma induced cytokine release syndrome is critically dependent on the expression of pore-forming Perforin-Like Protein-1

This study shows that Toxoplasma gondii's PLP1 protein drives cytokine release syndrome by inducing dysregulated immune responses, leading to lethal inflammation during acute infection.

CD103+ Dendritic Cell - Fibroblast Crosstalk via TLR9 and AHR Signaling Drives Lung Fibrogenesis

This study identifies CD103+ dendritic cell-fibroblast crosstalk via TLR9 and AHR signaling as a driver of lung fibrosis in IPF, showing that inhibiting AHR signaling reduces fibrosis.

Lung Microbiome Intervention Attenuates Herpesvirus-Induced Post-HCT Pulmonary Fibrosis Through PD-L1 Upregulation on Dendritic Cells

This study shows that heat-killed Lactobacillus johnsonii reduces herpesvirus-induced pulmonary fibrosis in HCT mice by increasing PD-L1 on dendritic cells, which suppresses Th17 cell IL-17A.

Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal women

This paper presents a single-cell RNA sequencing atlas of the human uterus, identifying 39 cell subtypes and proposing a consensus annotation system, while highlighting dynamic changes and potential progenitor cells across menstrual cycle phases.

Tcf21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration

This study identifies Tcf21+ mesenchymal progenitors in mouse testis that contribute to somatic cell development, homeostasis, and regeneration.