Resolving the Dynamic Interplay of the Conformational States in the TPR Domain of Human AMPylase FicD
Svenja Runge, Ecenaz Bilgen, Andrea Magni, Giorgio Bonollo, Giorgio Colombo, Aymelt Itzen, Don C. Lamb
This study uses smFRET to analyze conformational dynamics of FicD's TPR motifs, showing equilibrium between TPR-in and TPR-out states influenced by ATP and BiP.
Proceedings of the National Academy of Sciences · Aug 21, 2025Peer-reviewedBiophysics