Giorgio Colombo

BIOINF-farma integrates epitope prediction and developability assessment to prioritize vaccine candidates by combining antigenicity and expression feasibility scores.

This study identifies nanobody CDRs using deep learning and structural analysis, finding that their disorder and conformational diversity are adaptive features.

This study uses smFRET to analyze conformational dynamics of FicD's TPR motifs, showing equilibrium between TPR-in and TPR-out states influenced by ATP and BiP.

This study shows TRAP1 forms redox-sensitive tetramers via disulfide bonds, which are critical for its antioxidant and pro-neoplastic functions in cancer cells.

This study characterizes the molecular structure and enzymatic mechanism of GLT25D1/COLGALT, identifying its catalytic site and dimeric assembly as critical for collagen lysine modification.

This study uses molecular dynamics simulations to show that the V72I mutation in Hsp60 disrupts allosteric communication, rigidifying its complexes and impairing function.

This study investigates clinically relevant cytochrome c variants using bioinformatics and molecular dynamics to reveal structural and functional changes linked to thrombocytopenia 4.

This study examines how point mutations in TRAP1 affect its structure, function, and pro-neoplastic activity using molecular dynamics simulations and structural analysis.

The paper uses AlphaFold to predict the structure of sacsin's Hsp90-like domains and identifies key residues for ATPase activity, suggesting sacsin functions as an ATP-driven molecular chaperone.