Deoxyribonucleotide incorporation reshapes mRNA design beyond canonical ribonucleotide boundaries
Xiaoyan Ding, Rui Liao, Giovana Bampi, Dandan Zhang, Shan Guan, Joseph Rosenecker
This paper shows that substituting ribonucleotides with deoxyribonucleotides in mRNA improves translation efficiency and therapeutic potential in vivo.
bioRxiv · Jul 10, 2026 · PreprintSynthetic Biology