Joseph Rosenecker

This paper shows that substituting ribonucleotides with deoxyribonucleotides in mRNA improves translation efficiency and therapeutic potential in vivo.

The paper develops PoLixNano nanoparticles using machine learning to enhance mRNA delivery through nebulization, achieving high transfection efficiency and therapeutic efficacy in animal models.

This study shows airway mRNA vaccines need better purification and sequence design to avoid dsRNA contaminants, leading to improved immune responses.