Shan Guan

This study identifies ileal Gpbar1 as a peripheral node that regulates depressive behaviors via a gut-to-brain GABAergic axis, showing that agonism of Gpbar1 can reverse depressive-like phenotypes.

This paper shows that mucosal mRNA vaccines protect against Kp pneumonia via Tc17 cells, not antibodies, and introduces an exosome platform enhancing vaccine efficacy.

This paper shows that substituting ribonucleotides with deoxyribonucleotides in mRNA improves translation efficiency and therapeutic potential in vivo.

This paper identifies glucose as a reprogramming agent for the airway microenvironment to enhance mRNA delivery and efficacy in lung models.

This study identifies CNPY3 as an antiviral mediator suppressed by flaviviruses via HuR-mediated mRNA destabilization and demonstrates LNP-CNPY3 as a therapeutic approach to enhance antiviral responses.

The paper develops PoLixNano nanoparticles using machine learning to enhance mRNA delivery through nebulization, achieving high transfection efficiency and therapeutic efficacy in animal models.

This study shows airway mRNA vaccines need better purification and sequence design to avoid dsRNA contaminants, leading to improved immune responses.