DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change
Veronica M. Pravatà, Andrea Forero, Ane Cristina Ayo Martin, Giovanna Berto, Tim Heymann, Luise Fast, Matthias Mann, Stephan Riesenberg, Silvia Cappello
The paper identifies a human-specific mutation in DCHS1 that alters glycosylation and affects forebrain proportions by changing striatal and neocortical progenitor ratios.
bioRxiv · May 14, 2025 · PreprintNeuroscience