Tim Heymann

Aggregate Deep Visual Proteomics reveals selective organization of α-synuclein inclusions

This study uses Aggregate Deep Visual Proteomics to show that α-synuclein inclusions selectively concentrate specific proteins in neurons, revealing their formation mechanisms and potential therapeutic targets.

Scanning DIA on the ZenoTOF 8600 system records a precursor dimension for every fragment at tenfold higher ion flux

The paper introduces the ZenoTOF 8600 system, which enhances proteomics by increasing ion flux and improving precursor identification and quantification in DIA mode.

In situ polymerized monolith tips for reproducible, format-flexible proteomic sample preparation applied to biofluids

The paper introduces pSPEC, a reproducible proteomic sample preparation method for biofluids that increases protein identification by ~20% compared to in-solution plasma.

The diverse functions of viral microproteins

A >50,000-element viral smORF library screened by growth, MHC-I, ER stress, Perturb-seq and mass spectrometry yields >2,000 active microproteins and shows EBV BNLF2b inhibits PKA by mimicry.

Deep Visual Proteomics links vascular smooth muscle cell phenotypes to atherosclerotic plaque stability

This study uses Deep Visual Proteomics to analyze VSMC phenotypes in atherosclerotic plaques, finding spatially distinct phenotype distributions and a shift toward dedifferentiated states in unstable plaques.

HIP-MS: An ultra-high-throughput, sensitive, and versatile affinity enrichment platform for static and dynamic interactome profiling

HIP-MS is an automated platform for high-throughput interactome profiling that improves sensitivity and throughput compared to traditional AE-MS methods.

A cell type-resolved proteomic atlas of the human body

The paper constructs a cell type-resolved proteomic atlas of the human body using Deep Visual Proteomics, revealing protein abundance patterns and uncovering cancer-testis antigens in oocytes.

Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms

This study shows that inhibiting FKBP51 early in joint pain reduces both sensory and emotional symptoms for up to 6 months, while late inhibition only provides temporary relief.

A novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N labeled proteins

The paper introduces a novel hybrid mass spectrometer, Stellar MS, enabling rapid and sensitive clinical biomarker validation using 15N labeled proteins.

Solid-Phase Extraction Capture (SPEC) in nanoliter volumes for fast, robust and ultra-sensitive proteomics

The paper introduces SPEC, a proteomics sample preparation method that improves proteome depth and reproducibility from limited samples.

nanoPhos enables ultra-sensitive and cell-type resolved spatial phosphoproteomics

nanoPhos improves phosphoproteomics sensitivity and enables cell-type resolved spatial analysis of mouse brain tissue.

DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change

The paper identifies a human-specific mutation in DCHS1 that alters glycosylation and affects forebrain proportions by changing striatal and neocortical progenitor ratios.

AlphaDIA enables End-to-End Transfer Learning for Feature-Free Proteomics

AlphaDIA enables end-to-end transfer learning for feature-free proteomics, improving identification and quantification of post-translational modifications.

Involvement of FKBP5, but not of stress, in alcohol memory reconsolidation

This study investigates the role of FKBP5 and the HPA axis in alcohol memory reconsolidation, finding that FKBP51 inhibition affects cognitive flexibility but HPA axis manipulations do not impact reconsolidation.