Silvia Cappello

This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.

This study develops human cerebral assembloids to model glioblastoma interactions with glial cells, revealing extracellular vesicles' role in peritumoral niche formation.

The paper identifies JUNB as a gene driving species-specific cortical features by comparing gene expression in mouse, human, and human cortical organoids.

This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.

The paper identifies a human-specific mutation in DCHS1 that alters glycosylation and affects forebrain proportions by changing striatal and neocortical progenitor ratios.

This study shows chronic glucocorticoid exposure alters lineage specification in human neural organoids by priming inhibitory neuron fate through transcription factors like PBX3.

This study uses cerebral organoids to show that EPM1 mutations disrupt neural cell fate specification through intrinsic and extrinsic mechanisms involving EVs and SHH signaling.

This study investigates neuronal hyperactivity in human cerebral organoids derived from individuals with grey matter heterotopia, identifying functional and structural changes linked to the condition.

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

This study shows glucocorticoids increase specific basal progenitors via ZBTB16, leading to more neurons and linking to educational attainment and brain structure.

The paper investigates how extracellular vesicles (EVs) mediate developmental cues during brain development and disease, finding altered EV composition and function in neurodevelopmental disorders.

The paper shows that extracellular environment factors, specifically extracellular vesicles, influence neuronal differentiation and migration by altering transcriptomic profiles in neural progenitor cells.

The paper investigates how glucocorticoid receptor activation affects neuronal development in fetal human brain organoids using single-cell transcriptomics, finding cell-type specific impacts on differentiation and behavior-related gene expression.