Cross-Species Multi-Omics Profiling Identifies Conserved Activated Valvular Interstitial Cell Population Driving Myxomatous Mitral Valve Degeneration
Fu Gao, Ian Mason, Mingze Dong, Yue Lu, Di Zhang, Xing Lou, Irbaz Hameed, Mingyu Yang, Mei Zhong, Marcus Krane, Giovanni Ferrari, George Tellides, Yang Liu, Rong Fan, Arnar Geirsson
The paper identifies a conserved activated valvular interstitial cell population across species and disease types that drives myxomatous mitral valve degeneration.
bioRxiv · Mar 25, 2026 · PreprintMolecular Biology