George Tellides

This study identifies PDK4 as a regulator of TGF{beta}-mediated SMC contractility, showing that reducing PDK4 limits atherosclerosis by preserving SMC phenotype.

This study shows that C9, a component of membrane attack complexes, forms non-cytolytic intracellular aggregates that promote inflammation and EC activation through aggrephagy and NF-κB activation.

The paper investigates how hydraulic fracturing in aortic dissection causes medial damage beyond the false lumen, leading to structural weakening of the aortic wall.

This study investigates how increased medial collagen affects aortic resilience against mural delamination by analyzing pressure responses in human aortic specimens under different conditions.

The paper identifies a conserved activated valvular interstitial cell population across species and disease types that drives myxomatous mitral valve degeneration.

The paper investigates age-related changes in proximal pulmonary artery mechanics in mouse models, finding increased stiffness and collagen reorientation linked to aging biomarkers and cellular senescence.

This study identifies SPHK1 as a key driver of SMC hyperproliferation in elastin deficiency, showing its role in both pathological and physiological arterial remodeling.

The paper introduces Cryo-mtscATAC-seq to genotype mitochondrial DNA and trace clones in frozen human tissues, revealing clonal patterns in various diseases.

This study examines hypoxia-induced cardiopulmonary remodeling in mice, finding that pulmonary artery stiffening due to collagen remodeling precedes and correlates with cardiac and lung dysfunction, with partial recovery observed after normoxia.

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

The paper analyzes single-cell transcriptomes of aortic smooth muscle cells in mice to show distinct origins and similar transcriptional changes after TGFβ signaling disruption.