Orally active mGluR2/3 metabotropic antagonist pro-drug mimics the beneficial effects of physical exercise on neurogenesis, behavior, and exercise-related molecular pathways in an Alzheimer's disease mouse model
Georgina Perez-Garcia, Mesude Bicak, Jacqueline L. Buros, Jean‐Vianney Haure‐Mirande, Gissel M. Perez, Alena Otero‐Pagan, Miguel A. Gama Sosa, Rita De Gasperi, Mary C. Sano, Fred H. Gage, Carrolee Barlow, Joel T. Dudley, Benjamin Scott Glicksberg, Yanzhuang Wang, Benjamin P. Readhead, , Sam Gandy
This study shows that BCI-838, a mGluR2/3 antagonist, mimics exercise's benefits on neurogenesis, behavior, and molecular pathways in an Alzheimer's mouse model.
bioRxiv · Jan 31, 2022 · PreprintNeuroscience