Jean‐Vianney Haure‐Mirande

miR155 triplicated in Down syndrome regulates hippocampal GABAergic neurogenesis in Alzheimer's disease

The paper investigates miR155's role in hippocampal GABAergic neurogenesis in Alzheimer's disease, finding it regulates NSC dynamics and interneuron development with opposing effects compared to microglial miR155.

Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington's disease mouse phenotype

This study shows that deleting TYROBP in HD mice reduces microglial activation and improves motor deficits without correcting neuronal gene expression.

INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer's disease

The paper shows that INPP5D reduces plaque formation and glial reactivity in Alzheimer's disease mouse models through microglial knockdown and spatial transcriptomics analysis.

Orally active mGluR2/3 metabotropic antagonist pro-drug mimics the beneficial effects of physical exercise on neurogenesis, behavior, and exercise-related molecular pathways in an Alzheimer's disease mouse model

This study shows that BCI-838, a mGluR2/3 antagonist, mimics exercise's benefits on neurogenesis, behavior, and molecular pathways in an Alzheimer's mouse model.

Transcriptomic changes highly similar to Alzheimer's disease are observed in a subpopulation of individuals during normal brain aging

The paper identifies transcriptomic changes in normal aging brains that resemble Alzheimer's disease in specific subgroups, suggesting early molecular links between aging and LOAD.

Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice

This study shows that TYROBP-APOE signaling in microglia can occur without TREM2 and influences AD pathology in mouse models.

Further evidence of increased human Herpesvirus in Alzheimer's disease

The paper investigates the association between herpesviruses and Alzheimer's disease using multiomic data and simulations, finding increased HHV-6A abundance in AD brains.

Functional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse models

The paper identifies gene expression signatures in human and mouse brains linked to Alzheimer's disease and finds species-specific and shared patterns across neurodegenerative models.

Multiscale causal network models of Alzheimer’s disease identify VGF as a key regulator of disease

The paper identifies VGF as a key regulator of Alzheimer’s disease using multiscale causal network models and validates its protective role in mouse models.