Author

Giulia Ambrosi

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Michael BoutrosiD· 2 shared Antonia Franziska EckertiD· 1 shared Dominique KranziD· 1 shared Gerd Ulrich NienhausiD· 1 shared Katharina ImkelleriD· 1 shared Oksana VoloshanenkoiD· 1 shared Wolfgang K. HuberiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersGenetics

Michael BoutrosORCID

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2 papers

Recent·Most cited

Allele-specific endogenous tagging and quantitative analysis of beta-catenin in colorectal cancer cells

Giulia Ambrosi, Oksana Voloshanenko, Antonia Franziska Eckert, Dominique Kranz, Gerd Ulrich Nienhaus, Michael Boutros

This study uses genome engineering to fluorescently tag wild-type and mutant beta-catenin alleles in colorectal cancer cells, revealing distinct biophysical properties and showing how Wnt signaling modulates wild-type behavior to resemble the mutant form.

bioRxiv · Jun 18, 2020 · PreprintGenetics

Modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection

Katharina Imkeller, Giulia Ambrosi, Michael Boutros, Wolfgang K. Huber

The paper develops a statistical test to improve hit detection in CRISPR screens by accounting for asymmetric gRNA abundance changes, allowing smaller experiment sizes.

Genome biology · Mar 2, 2020Peer-reviewedBioinformatics