Dominique Kranz

This study shows that the N-terminus of Wnt proteins determines their secretion and signaling properties, with Wnt11's N-terminus enabling Evi/Wls-independent secretion and Frizzled 6 activation.

The paper identifies regulators of Dvl2 biomolecular condensates using image-based screens and phosphoproteomics, finding CK1δ/ε inhibition blocks condensate formation and modulates Wnt signaling.

This study uses genome engineering to fluorescently tag wild-type and mutant beta-catenin alleles in colorectal cancer cells, revealing distinct biophysical properties and showing how Wnt signaling modulates wild-type behavior to resemble the mutant form.