Oksana Voloshanenko

Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer

This study shows Wnt10b signaling prevents replication stress-induced chromosomal instability in cancer cells by suppressing microtubule dynamics and chromosome missegregation.

Secretion and signaling properties of Wnt11 and Wnt3 are determined by their N-terminus

This study shows that the N-terminus of Wnt proteins determines their secretion and signaling properties, with Wnt11's N-terminus enabling Evi/Wls-independent secretion and Frizzled 6 activation.

Image-based screens identify regulators of endogenous Dvl2 biomolecular condensates

The paper identifies regulators of Dvl2 biomolecular condensates using image-based screens and phosphoproteomics, finding CK1δ/ε inhibition blocks condensate formation and modulates Wnt signaling.

Allele-specific endogenous tagging and quantitative analysis of beta-catenin in colorectal cancer cells

This study uses genome engineering to fluorescently tag wild-type and mutant beta-catenin alleles in colorectal cancer cells, revealing distinct biophysical properties and showing how Wnt signaling modulates wild-type behavior to resemble the mutant form.

Towards an Integrated Map of Genetic Interactions in Cancer Cells

The paper develops MINGLE, a computational framework to integrate CRISPR/Cas9 screens and identify genetic interactions in cancer cells, revealing new vulnerabilities and building a large genetic network.