GeneticsbioRxivPreprint
Allele-specific endogenous tagging and quantitative analysis of beta-catenin in colorectal cancer cells
Giulia Ambrosi, Oksana Voloshanenko, Antonia Franziska Eckert…·Michael Boutros
This study uses genome engineering to fluorescently tag wild-type and mutant beta-catenin alleles in colorectal cancer cells, revealing distinct biophysical properties and showing how Wnt signaling modulates wild-type behavior to resemble the mutant form.
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