The Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells
Maria–Graciela Delgado, Ann-Kathrin Burkhart, Charlotte Canet-Jourdan, Javiera Villar, Roberto Amadio, Vanessa Samira Rácz, Doriane Sanséau, Nilushi De Silva, Lívia Lacerda Mariano, Anna Shmakova, Anna Chipont, Mabel J. Jouve, Giulia Bracchetti, Vincent Calmettes, Zahraa Alraies, , Sandra Iden
This study shows that the Arp2/3 complex is essential for genome integrity and survival of epidermal Langerhans cells, with Arpc4 deficiency leading to DNA damage and premature aging-like decline.
bioRxiv · Dec 27, 2024 · PreprintCell Biology