This study develops a mouse model of hypertensive emergency with multiorgan microvascular disease and identifies dysregulated VEGFA/sFlt-1 signaling as a key driver.

bioRxiv · Mar 6, 2026 · PreprintPathology

The Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells

Maria–Graciela Delgado, Ann-Kathrin Burkhart, Charlotte Canet-Jourdan, Javiera Villar, Roberto Amadio, Vanessa Samira Rácz, Doriane Sanséau, Nilushi De Silva, Lívia Lacerda Mariano, Anna Shmakova, Anna Chipont, Mabel J. Jouve, Giulia Bracchetti, Vincent Calmettes, Zahraa Alraies, , Sandra Iden

This study shows that the Arp2/3 complex is essential for genome integrity and survival of epidermal Langerhans cells, with Arpc4 deficiency leading to DNA damage and premature aging-like decline.

bioRxiv · Dec 27, 2024 · PreprintCell Biology

Tunable DNMT1 degradation reveals cooperation of DNMT1 and DNMT3B in regulating DNA methylation dynamics and genome organization

Andrea Scelfo, Viviana Barra, Nezar A. Abdennur, George Spracklin, Florence Busato, Catalina Salinas‐Luypaert, Elena Bonaiti, Guillaume Velasco, Anna Chipont, Coralie L. Guérin, Andréa E. Tijhuis, Diana C.J. Spierings, Claire Francastel, Floris Foijer, Jörg Tost, , Daniele Fachinetti

This study uses tunable DNMT1 degradation to investigate DNA methylation dynamics and genome organization, revealing cooperative roles of DNMT1 and DNMT3B and their impact on heterochromatin and cell fitness.

bioRxiv · May 4, 2023 · PreprintMolecular Biology