Ubiquitin-dependent degradation of p21Waf1/Cip1 is mediated by AMBRA1 to limit DNA replication stress
Giacomo Milletti, Giulia Cadeddu, Alba Adelantado-Rubio, Caterina Ferraina, Kristina Keuper, Sebastian Howen Nesgaard Munk, Cristiano De Stefanis, Denise Quacquarini, Sabrina Rossi, Angela Mastronuzzi, Franco Locatelli, Paolo Grumati, Valentina Cianfanelli, Francesca Nazio, Jiri Jr Bartek, , Francesco Cecconi
This study shows that AMBRA1 promotes the ubiquitin-dependent degradation of p21Waf1/Cip1 to prevent DNA replication stress and supports its role as a prognostic marker in medulloblastoma.
bioRxiv · Jul 28, 2025 · PreprintMolecular Biology