Paolo Grumati

This study identifies a non-canonical role for the LC3C-ATG4D axis in supporting coronavirus replication organelle formation, independent of canonical autophagy.

This study reveals that autophagy selectively clears the endoplasmic reticulum during inflammation-induced muscle atrophy, challenging the classical view of atrophy as a uniform degradation process.

This study identifies a mechanical regulation pathway involving Src-FAK-AMPK-GBF1 that controls cargo sorting and secretion from the Golgi in response to substrate stiffness.

This study shows that AMBRA1 promotes the ubiquitin-dependent degradation of p21Waf1/Cip1 to prevent DNA replication stress and supports its role as a prognostic marker in medulloblastoma.

The paper introduces MACanalyzeR, a scRNA-seq tool, to identify PPARγ-high lipid-associated macrophages in BAT that support thermogenic expansion.

This study develops a feeder-free serum-coated system for culturing naive human pluripotent stem cells, maintaining their developmental potential and reducing contamination and mutations.

The paper identifies Ezrin's role in regulating TSC complex activation at endosomes via EGFR-AKT signaling, showing its impact on mTORC1 and retinal function.