Francesco Cecconi

Selective autophagy of whole micronuclei suppresses chromosomal instability

The paper shows that autophagy selectively degrades micronuclei with nuclear envelope defects, preventing chromosomal instability by eliminating missegregated chromosomal material.

Ubiquitin-dependent degradation of p21Waf1/Cip1 is mediated by AMBRA1 to limit DNA replication stress

This study shows that AMBRA1 promotes the ubiquitin-dependent degradation of p21Waf1/Cip1 to prevent DNA replication stress and supports its role as a prognostic marker in medulloblastoma.

The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma

The paper introduces Cancermuts, a Python tool for prioritizing missense cancer variants, and validates its predictions on AMBRA1 mutations in melanoma.