Ubiquitin-dependent degradation of p21Waf1/Cip1 is mediated by AMBRA1 to limit DNA replication stress
Giacomo Milletti, Giulia Cadeddu, Alba Adelantado-Rubio…·Francesco Cecconi
This study shows that AMBRA1 promotes the ubiquitin-dependent degradation of p21Waf1/Cip1 to prevent DNA replication stress and supports its role as a prognostic marker in medulloblastoma.