Targeting CXCR4-expressing TAMs in muscle-invasive bladder cancer to enhance tumor control after immunotherapy
Emma Desponds, Hajar El Ahanidi, Nagham Alouche, Hana Zdimerova, Stéphanie Favre, Giulio Zanette, Sina Nassiri, Daniel A. Benamran, Petros K. Tsantoulis, Mohammed Attaleb, Hélène Maby-El Hajjami, Julien Dagher, Vanessa Gourhand, Karl Balabanian, Marion Espéli, , Grégory Verdeil
This study identifies CXCR4-expressing tumor-associated macrophages in bladder cancer and shows that targeting them improves immunotherapy outcomes in mice and patients.
bioRxiv · Mar 21, 2025 · PreprintImmunology