Heparin flexibility within the extracellular matrix determines the bioactivity of bound vascular endothelial growth factor
Giuseppe Trapani, Daniele Di Iorio, Jurij Froese, Saskia Winter, Seraphine Valeska Wegner, Kay Grobe, Britta Trappmann
This study shows that heparin flexibility in the extracellular matrix affects VEGF mobility and bioactivity by influencing its interaction with VEGF receptor 2.
bioRxiv · Mar 11, 2025 · PreprintBioengineering