Daniele Di Iorio

Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned

This study compares the structural and functional mechanisms of Mon1-Ccz1 and Fuzzy-Inturned RabGEFs to explain their target specificity and membrane recruitment.

Heparin flexibility within the extracellular matrix determines the bioactivity of bound vascular endothelial growth factor

This study shows that heparin flexibility in the extracellular matrix affects VEGF mobility and bioactivity by influencing its interaction with VEGF receptor 2.

Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility

This study shows that Omicron SARS-CoV-2 spike proteins balance heparan sulfate interaction stability and dynamics to enhance mobility in the extracellular matrix, which can be targeted pharmacologically.