Author

Jurij Froese

University of Münster

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Kay GrobeiD· 4 shared Seraphine Valeska WegneriD· 3 shared Daniele Di IorioiD· 2 shared Alexander N.R. WeberiD· 1 shared Alexandra Großdorf· 1 shared Anayancy Osorio‐MadrazoiD· 1 shared Antonella BisioiD· 1 shared Britta TrappmanniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMolecular Biology

Kay GrobeORCID

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Author profile →

4 papers

Recent·Most cited

Chitinase-3-like protein 1 decodes chitosan acetylation patterns into toll-like receptor 2 signaling through heparan sulfate

Alexandra Großdorf, Sina Nabil, Carlotta Imelmann, Margareta J. Hellmann, Jurij Froese, Ehab El‐Awaad, Tuan Anh Tran, Stefan Cord‐Landwehr, Nick Rähse, Önder Kurç, Fuzhu Yang, Hung-Yu Chen, Evelyne Gout, Gabriela Rosca, Marion Kusche‐Gullberg, , Christian Gorzelanny

This study shows CHI3L1 interacts with chitosan and heparan sulfate to activate TLR2 signaling, revealing HS as a co-receptor for CHI3L1 and its role in inflammation.

bioRxiv · Jun 16, 2026 · PreprintMolecular Biology

Scube2 primes Dispatched and ADAM10-mediated Shh release by recruiting HDL acceptors to the plasma membrane

Janna Puschmann, Georg Steffes, Jurij Froese, Dominique Manikowski, Kristina Ehring, J. Wittke, Christoph Garbers, S. V. Wegner, Kay Grobe

This study identifies Scube2's role in enhancing Shh release by recruiting lipoprotein acceptors and interacting with heparan sulfate on the plasma membrane.

Communications Biology · Jan 8, 2026Peer-reviewedCell Biology

Heparin flexibility within the extracellular matrix determines the bioactivity of bound vascular endothelial growth factor

Giuseppe Trapani, Daniele Di Iorio, Jurij Froese, Saskia Winter, Seraphine Valeska Wegner, Kay Grobe, Britta Trappmann

This study shows that heparin flexibility in the extracellular matrix affects VEGF mobility and bioactivity by influencing its interaction with VEGF receptor 2.

bioRxiv · Mar 11, 2025 · PreprintBioengineering

Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility

Jurij Froese, Marco Mandalari, Monica Civera, Stefano Elli, Isabel Pagani, Elisa Vicenzi, Itzel Garcia‐Monge, Daniele Di Iorio, Saskia Frank, Antonella Bisio, Dominik Lenhart, Rudolf Gruber, Edwin Alexander Yates, Ralf P. Richter, Marco Guerrini, , Kay Grobe

This study shows that Omicron SARS-CoV-2 spike proteins balance heparan sulfate interaction stability and dynamics to enhance mobility in the extracellular matrix, which can be targeted pharmacologically.

Scientific Reports · Dec 31, 2024Peer-reviewedMolecular Biology