Glucose-Fueled Histone Modifications Drive HIV-1 Latency Reversal at Hypoxia
Yetunde I. Kayode, Deanna C. Clemmer, Adebola A. Owolabi, AbdulKareem A. AlShaheeb, Elyse K. McMahon, Anna Tangiyan, Lauren Clark, Glenn E. Simmons, Alberto Bosque, Melanie R. McReynolds, Harry E. Taylor
This study identifies glucose and oxygen as critical metabolic factors influencing HIV-1 latency reversal, showing that glucose fuels histone lactylation and chromatin accessibility at the HIV promoter.
bioRxiv · Sep 14, 2025 · PreprintImmunology