Alberto Bosque

This study shows that Fc-engineered broadly neutralizing antibodies enhance NK cell ADCC against HIV-1 across subtypes, even with limited envelope binding and CD16 downregulation.

The paper shows HIV uses Vpr to increase TRAIL-R2 expression in CD4+ T cells, which enhances NK cell killing through non-canonical TRAIL signaling.

This study identifies glucose and oxygen as critical metabolic factors influencing HIV-1 latency reversal, showing that glucose fuels histone lactylation and chromatin accessibility at the HIV promoter.

The paper shows that tazemetostat reduces HIV reservoirs and improves CD8+ T-cell function by increasing MHC-I expression and promoting anti-HIV immune responses.