Enhanced delivery of lipid nanoparticle-based immunotherapy by modulating the tumor tissue stiffness using ultrasound-activated nanobubbles
Anubhuti Bhalotia, Diarmuid W. Hutchinson, Theresa Kosmides, Pinunta Nittayacharn, Meghna Mehta, Arya Iyer, Andrew Cheplyansky, Kayo Takizawa, Abraham Nidhiry, Ann M. Dever, Kyle A. Cousens, Inga M. Hwang, Gopalakrishnan Ramamurthy, Agata A. Exner, Efstathios Karathanasis
This study shows that ultrasound-activated nanobubbles reduce tumor stiffness and enhance lipid nanoparticle delivery and immunotherapy efficacy.
ACS Nano · Jan 28, 2026Peer-reviewedBioengineering