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Gordon J. Murray

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Molecular Biology· 1

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Approach:experimental assay· 1

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Arjun Jha· 1 shared Costas Andreas LyssiotisiD· 1 shared Giovanna Christinne Rocha de Medeiros· 1 shared Hyunsu LeeiD· 1 shared Joseph H. LaPointe· 1 shared Kendall Marie MuzzarelliiD· 1 shared Narges Pourmandi· 1 shared Shomit Sengupta· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperMolecular Biology

Arjun Jha

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1 paper

Recent·Most cited

Purine nucleotides are competitive inhibitors of apo-GOT1

Narges Pourmandi, Arjun Jha, Kendall Marie Muzzarelli, Hyunsu Lee, Zahra Assar, Gordon J. Murray, Joseph H. LaPointe, Thomas P. Roddy, Giovanna Christinne Rocha de Medeiros, Shomit Sengupta, Costas Andreas Lyssiotis

The paper identifies purine nucleotides as competitive inhibitors of apo-GOT1 by showing they bind to the PLP pocket and destabilize the enzyme in its cofactor-free state.

bioRxiv · Sep 17, 2025 · PreprintMolecular Biology