Author

Narges Pourmandi

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Arjun Jha· 2 shared Costas Andreas LyssiotisiD· 2 shared Aaron D. denDekkeriD· 1 shared Amanda D. Sankar· 1 shared Cristina CastilloiD· 1 shared Dominik AwadiD· 1 shared Giovanna Christinne Rocha de Medeiros· 1 shared Gordon J. Murray· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Arjun Jha

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Purine nucleotides are competitive inhibitors of apo-GOT1

Narges Pourmandi, Arjun Jha, Kendall Marie Muzzarelli, Hyunsu Lee, Zahra Assar, Gordon J. Murray, Joseph H. LaPointe, Thomas P. Roddy, Giovanna Christinne Rocha de Medeiros, Shomit Sengupta, Costas Andreas Lyssiotis

The paper identifies purine nucleotides as competitive inhibitors of apo-GOT1 by showing they bind to the PLP pocket and destabilize the enzyme in its cofactor-free state.

bioRxiv · Sep 17, 2025 · PreprintMolecular Biology

Aspartate transaminases are required for blood development

Narges Pourmandi, Greggory Myers, Arjun Jha, Kelsey Temprine, Amanda D. Sankar, Nupur Kanti Das, Ridwana Khan, Siva Kumar Natarajan, Cristina Castillo, Peter Sajjakulnukit, Noah S. Nelson, Matthew D. Perricone, Indrani Talukder, Aaron D. denDekker, Lin Lin, , Costas Andreas Lyssiotis

This study identifies aspartate transaminases GOT1 and GOT2 as critical for erythropoiesis by linking metabolism to epigenetic regulation, revealing a novel role in blood development.

bioRxiv · Sep 16, 2025 · PreprintBiochemistry