Molecular BiologybioRxivPreprint
Purine nucleotides are competitive inhibitors of apo-GOT1
Narges Pourmandi, Arjun Jha, Kendall Marie Muzzarelli…·Costas Andreas Lyssiotis
The paper identifies purine nucleotides as competitive inhibitors of apo-GOT1 by showing they bind to the PLP pocket and destabilize the enzyme in its cofactor-free state.
DOI 10.1101/2025.09.17.676921