Author

Shomit Sengupta

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Molecular Biology· 1

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Approach:experimental assay· 1

Frequent Co-Authors

Arjun Jha· 1 shared Costas Andreas LyssiotisiD· 1 shared Giovanna Christinne Rocha de Medeiros· 1 shared Gordon J. Murray· 1 shared Hyunsu LeeiD· 1 shared Joseph H. LaPointe· 1 shared Kendall Marie MuzzarelliiD· 1 shared Narges Pourmandi· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Arjun Jha

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1 paper

Recent·Most cited

Purine nucleotides are competitive inhibitors of apo-GOT1

Narges Pourmandi, Arjun Jha, Kendall Marie Muzzarelli, Hyunsu Lee, Zahra Assar, Gordon J. Murray, Joseph H. LaPointe, Thomas P. Roddy, Giovanna Christinne Rocha de Medeiros, Shomit Sengupta, Costas Andreas Lyssiotis

The paper identifies purine nucleotides as competitive inhibitors of apo-GOT1 by showing they bind to the PLP pocket and destabilize the enzyme in its cofactor-free state.

bioRxiv · Sep 17, 2025 · PreprintMolecular Biology