Antibody responses against bacterial glycans affinity mature and diversify in germinal centers.
Holly A. Fryer, Catherine Pitt, Hannah R. C. Frost, Nitika Kandhari, Sean Byars, Pailene S. Lim, Rhiannon L. Fettes, Reece M. Lovett, Trang T. Nguyen, Kaneka Chheng, Natalie Caltabiano, Alana L. Whitcombe, Julianne Hamelink, Dean W. Andrew, Gordon Lloyd, , Danika Lea Hill
The paper shows that glycan-specific B cells undergo class-switching and diversification in germinal centers with age and infection, influencing vaccine design.
Immunity · Mar 1, 2026Peer-reviewedImmunology