Dean W. Andrew

The paper characterizes malaria-specific Tfh and Tr1 cells in a longitudinal cohort, finding overlapping phenotypes and showing their decline after transmission interruption.

The paper shows that glycan-specific B cells undergo class-switching and diversification in germinal centers with age and infection, influencing vaccine design.

This study compares CD4 T cell responses to Plasmodium falciparum and P. vivax malaria, finding similar activation and proliferation but species-specific differences in peripheral Tfh cell subsets and IL-10 production.

This study shows that latent cytomegalovirus infection reduces NK cell responses to Plasmodium falciparum and impairs parasite control by disrupting IL-12 production.

The paper investigates age-related differences in inflammatory responses to malaria, finding that adults exhibit heightened inflammatory cytokine production and distinct transcriptional responses compared to children.

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.