Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease
Yanya Ding, Jingyu Feng, Viollandi Prifti, Grace A. Rico, Alexander G. Solorzano, Hayley E Chang, Samantha Spallina, Edward G. Freedman, John J. Foxe, Kuan Hong Wang
This study links age- and sex-dependent auditory neurophysiological deficits in Cln3-/- mice to region-specific lysosomal storage pathology in the auditory thalamocortical circuit.
bioRxiv · Jun 4, 2026 · PreprintNeuroscience