Edward G. Freedman

Neural and Gait Adaptations to Dual-Task Demands in Children and Young Adults: A Mobile Brain-Body Imaging (MoBI) Study.

This study examines how cognitive-motor interactions develop from childhood to young adulthood using dual-task paradigms and mobile brain-body imaging, finding age-related changes in neural and motor responses.

Longitudinal Exploration of Auditory Sensory-Perceptual Processing in CLN3 Disease (Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease)): A High-Density Auditory Evoked Potential (AEP) Study.

This study uses high-density EEG to examine longitudinal changes in auditory processing in CLN3 disease patients compared to controls, finding age-related amplitude differences in auditory evoked potentials.

Processing of Emotional Faces Has Unique Functional and Cytoarchitectural Associations in those with an Autism Spectrum Diagnosis.

The study investigates the relationship between neuron density and functional activity in the amygdala during emotional face processing in individuals with ASD compared to neurotypical controls.

Functional ultrasound imaging reveals pathway-specific visual system reorganization in young Cln3-/- mice

This study uses functional ultrasound imaging to show pathway-specific functional and pathological changes in the visual system of young Cln3-/- mice before severe retinal degeneration.

Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease

This study links age- and sex-dependent auditory neurophysiological deficits in Cln3-/- mice to region-specific lysosomal storage pathology in the auditory thalamocortical circuit.

Atypical somatosensory adaptation in adults on the autism spectrum: a high-density electrophysiological (EEG) mapping study.

This study examines tactile adaptation in autistic and neurotypical adults using EEG, finding preserved short-term adaptation but heightened re-sensitization in autistic individuals.

Neural markers of visual working memory during an upper extremity movement-coupled task: a mobile brain-body imaging (MOBI) study.

This study uses a mobile brain-body imaging system to examine how visual working memory load affects neural activity and motor performance during an upper extremity task, finding load-related changes in parieto-occipital and posterior-frontal brain activity.

Sex-specific and age-related progression of auditory neurophysiological deficits in the Cln3 mouse model of Batten disease

This study investigates sex-specific and age-related auditory neurophysiological deficits in Cln3-/- mice using MMN paradigms, revealing central auditory processing issues that mirror human CLN3 disease findings.

Neurophysiological measures of covert semantic processing in neurotypical adolescents actively ignoring spoken sentence inputs: A high-density event-related potential (ERP) study.

This study investigates whether semantic processing occurs covertly in adolescents ignoring spoken sentences, finding robust N400 and LPC/P600 responses despite reduced amplitudes and delayed latencies.

Intact Somatosensory Temporal Sensitivity in Adults on the Autism Spectrum: A High-Density Electrophysiological Mapping Study Using the Mismatch Negativity (MMN) Sensory Memory Paradigm.

This study uses high-density electrophysiological mapping to compare somatosensory temporal sensitivity between autistic and neurotypical adults using the MMN paradigm, finding no group differences in discrimination but subtle amplitude differences.

It's all in the timing: Delayed feedback in autism may weaken predictive mechanisms during contour integration

This study finds delayed feedback in autism spectrum disorder (ASD) during visual contour integration, suggesting weakened predictive mechanisms in sensory processing.

Reduced Proactive and Reactive Cognitive Flexibility in Older Adults Underlies Performance Costs During Dual-Task Walking: A Mobile Brain/Body Imaging (MoBI) Study

This study investigates age-related differences in cognitive flexibility during dual-task walking, finding reduced proactive and reactive control in older adults leading to increased performance costs.

Probing the neurophysiology of temporal sensitivity in the somatosensory system using the mismatch negativity (MMN) sensory memory paradigm.

This study uses a somatosensory mismatch negativity paradigm to investigate how the brain processes vibrotactile duration, finding that sMMN responses correlate with individual ability to detect duration deviants.

Maintaining task performance levels under cognitive load while walking requires widespread reallocation of neural resources: A Mobile Brain-Body Imaging (MoBI) study.

This study investigates how neural resources are reallocated during walking under increased cognitive load using MoBI, finding attenuated EEG amplitude changes without performance costs.

Paradoxical improvement of cognitive control in older adults under dual-task walking conditions is associated with more flexible reallocation of neural resources: A Mobile Brain-Body Imaging (MoBI) study.

This study finds that older adults show improved cognitive task performance during dual-task walking, associated with flexible neural resource reallocation, while younger adults also show similar improvements.

Autism is Associated with in vivo Changes in Gray Matter Neurite Architecture.

The paper uses diffusion-weighted imaging to identify decreased neurite density and altered diffusion patterns in autistic individuals compared to controls and other psychiatric conditions.

Evoking the N400 Event-Related Potential (ERP) Component Using a Publicly Available Novel Set of Sentences with Semantically Incongruent or Congruent Eggplants (Endings).

The paper develops a publicly available set of 404 sentences with semantically incongruent or congruent endings to elicit N400 ERP components and validates its use in neurotypical adults.

The strength of feedback processing is associated with resistance to visual backward masking during illusory contour processing in adult humans.

This study links feedback processing strength, measured via VEP modulation, to individual differences in resistance to visual backward masking during illusory contour detection in humans.

Young adults who improve performance during dual-task walking show more flexible reallocation of cognitive resources: A Mobile Brain-Body Imaging (MoBI) study.

The paper investigates cognitive flexibility during dual-task walking using MoBI, finding that improved performance is linked to specific EEG changes and gait stability.

Enhanced anticipatory biasing of visuospatial attention in deaf native-signing adults indexed by alpha-band (8-14 Hz) oscillatory neural activity

This study investigates whether deaf native signers show enhanced visuospatial attention abilities through alpha-band oscillatory neural activity, finding earlier and more extensive anticipatory alpha activity compared to hearing participants.

Learning a new class of multisensory associations: High-density electrophysiological mapping of the temporal course of audio-visual object processing.

The paper investigates the brain processes involved in learning and identifying novel audio-visual objects using high-density ERPs and identifies three stages of multisensory processing.

Individuals with autism have no detectable deficit in neural markers of prediction error when presented with auditory rhythms of varied temporal complexity

The study finds no difference in neural prediction error responses between individuals with ASD and neurotypical controls to auditory rhythms of varying complexity.

Auditory sensory memory span for duration is severely curtailed in females with Rett Syndrome.

This study uses MMN to show that females with Rett Syndrome have reduced duration sensory memory span compared to typically developing controls.