Kuan Hong Wang

A cross-species protocol for ultrasound-guided intrauterine injections across gestation

This paper presents a cross-species protocol for ultrasound-guided prenatal gene delivery to the nervous system in rats and marmosets, enabling safe and selective intrauterine manipulation.

Functional ultrasound imaging reveals pathway-specific visual system reorganization in young Cln3-/- mice

This study uses functional ultrasound imaging to show pathway-specific functional and pathological changes in the visual system of young Cln3-/- mice before severe retinal degeneration.

Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease

This study links age- and sex-dependent auditory neurophysiological deficits in Cln3-/- mice to region-specific lysosomal storage pathology in the auditory thalamocortical circuit.

Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity

This study identifies aIC-to-mPFC neural circuitry as critical for cognitive flexibility and shows that targeting this pathway can restore cognitive flexibility in stressed mice.

Projection-Specific Intersectional Optogenetics for Precise Excitation and Inhibition in the Marmoset Brain

The paper develops an optogenetic method to selectively excite and inhibit projection-specific neurons in marmosets, enabling precise modulation of neural circuits.

Targeted gene transfer into developmentally defined cell populations of the primate brain

This paper introduces a method for targeted gene transfer into specific cell populations of the fetal primate brain using ultrasound-guided viral injections.

Sex-specific and age-related progression of auditory neurophysiological deficits in the Cln3 mouse model of Batten disease

This study investigates sex-specific and age-related auditory neurophysiological deficits in Cln3-/- mice using MMN paradigms, revealing central auditory processing issues that mirror human CLN3 disease findings.

Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the frontal cortex.

This study shows that dopaminergic signaling in adolescence affects microglial behavior and axonal plasticity in the frontal cortex, with potential therapeutic implications for adult brain plasticity.

Cholecystokinin from the Rhinal Cortex Facilitates Motor Skill Learning

This study shows that cholecystokinin (CCK) from the rhinal cortex supports motor skill learning by enabling neuroplasticity in the motor cortex.

Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

The paper shows that adolescent neurostimulation of dopamine circuits can reverse cognitive deficits in genetic mouse models.

Fast prediction in marmoset reach-to-grasp movements for dynamic prey

This study examines marmoset reach-to-grasp movements for dynamic prey, finding very short visuo-motor delays and visual prediction compensating for these delays during fast reaching.

Hearing loss promotes schizophrenia-relevant brain and behavioral abnormalities in a mouse model of human 22q11.2 Deletion Syndrome

This study shows that hearing loss in a mouse model of 22q11.2 Deletion Syndrome affects schizophrenia-relevant brain and behavioral abnormalities, including auditory gain and PV+ interneuron density in the auditory cortex.