Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish
Svetlana A. Semenova, Deepthi Nammi, Grace Garrett, Gennady Margolin, Jennifer L. Sinclair, Reza Maroofian, Keith W. Caldecott, Harold A. Burgess
The paper shows that parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish, suggesting PARP1 inhibition could be therapeutic for neurological disorders.
Scientific Reports · May 16, 2025Peer-reviewedNeuroscience