Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity
Hannah Neiswender, Jessica E Pride, Rajalakshmi Veeranan‐Karmegam, Phylicia Allen, Grace Neiswender, Avneesh Prabakar, Caili Hao, Xingjun Fan, Graydon B. Gonsalvez
This study identifies BICD2 mutations linked to SMALED2 that cause dynein hyperactivity and interactome changes, contributing to disease pathology.
eLife · Dec 3, 2025Peer-reviewedCell Biology