Xingjun Fan

β-Amyloid and Glutathione Dysregulation Cooperatively Drive Lipid Peroxidation and Ferroptosis in Neuron-Like Cells

This study shows that impaired glutathione (GSH) and β-amyloid (Aβ) synergistically drive lipid peroxidation and ferroptosis in neuron-like cells, highlighting redox dysregulation as a key factor in Alzheimer's disease.

Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

This study identifies BICD2 mutations linked to SMALED2 that cause dynein hyperactivity and interactome changes, contributing to disease pathology.