Graydon B. Gonsalvez

An in vivo examination of Dynein-Cargo complex formation.

This study identifies Bicaudal-D and Centrocortin as dynein adaptors in Drosophila egg chambers, showing distinct mechanisms for their interaction with dynein and implications for cargo transport.

Proteomic profiling of cytoskeletal interactomes using MT-ID and Act-ID.

This paper introduces MT-ID and Act-ID, proximity-labeling tools to identify microtubule and actin-interacting proteins, and discovers novel regulators like LIMCH1 and FBXO30.

To Be or Not to Be an Oocyte: Msps/XMAP215 Controls Oocyte Cell Fate in the Drosophila Ovary

This study shows Msps/XMAP215 promotes oocyte fate by enhancing microtubule polymerization and Orb accumulation, leading to asymmetric distribution and positive feedback in Drosophila.

Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

This study identifies BICD2 mutations linked to SMALED2 that cause dynein hyperactivity and interactome changes, contributing to disease pathology.

A region of Drosophila SLBP distinct from the histone pre-mRNA binding and processing domains is essential for deposition of histone mRNA in the oocyte

The paper identifies a 10 aa region in Drosophila SLBP essential for histone mRNA transcription in stage 10b oocytes, despite not being required for in vitro processing.

Deficiency in the endocytic adaptor protein PHETA1/2 impairs renal and craniofacial development

This study investigates the role of PHETA1/2 in zebrafish, showing that their deficiency causes renal and craniofacial defects, and links a patient variant to disease pathogenesis.