Acute Paternal Immune Activation Shapes Embryonic Development and Protects Offspring from Viral Infection
Taylor Miller-Ensminger, Ariana D. Campbell, Elizabeth A. Kennedy, Madeline N Lamonica, Cecelia Murphy, Grace S. Lee, Mia Weller, Montserrat Carolina Arreguin, Madeline S. Merlino, Seble G. Negatu, Peter Hewins, Colin C. Conine, Kellie A. Jurado
This study shows that acute paternal immune activation alters sperm small RNAs, which reprogram embryonic gene expression and enhance offspring survival from viral infection.
bioRxiv · Mar 10, 2026 · PreprintImmunology