Colin C. Conine

The paper compares small and large extracellular vesicles from healthy pregnancies to identify subtype-specific cargo differences and establish a reference for normal EV biology.

This study shows epididymal extracellular vesicles transfer mRNAs to sperm, which then influence early embryo gene expression.

The paper shows that small variations in sperm miRNAs can influence embryonic gene expression and developmental outcomes through direct and secondary mechanisms.

The paper shows that tRNA-derived RNAs (tDRs) in sperm of C. elegans can transmit epigenetic phenotypes to offspring through RNaseT2-mediated regulation of tDR length.

This study shows that acute paternal immune activation alters sperm small RNAs, which reprogram embryonic gene expression and enhance offspring survival from viral infection.

This study identifies immune cell populations in the developing rat pancreas and spleen, showing IUGR disrupts their composition and is influenced by tissue environment and sex.

The paper identifies pseudouridine as a key modification enabling RNA extracellular transport and identifies MYL6 as a binding protein required for this process.

This study shows that maternal extracellular vesicles from COVID-19 pregnancies alter trophoblast function, contributing to placental dysfunction.

This study shows that sub-chronic heat stress alters sperm small non-coding RNA profiles in mice, leading to accelerated embryonic development and fetal weight gain.

The paper introduces LIDAR, a ligation-independent sequencing method that captures diverse RNA species, including tRNA-derived RNAs with blocked 3' termini, in mouse cells.

The paper shows that a mutation in Khdc3 in ancestral mice leads to transgenerational metabolic defects in offspring through epigenetic changes in gametes.

The paper examines how different fertilization methods affect preimplantation gene regulation in mouse embryos, identifying stable and flexible gene expression patterns and the role of sperm RNAs in development.

The paper examines cytosine methylation changes in sperm during post-testicular maturation and finds minimal changes, with an unexpected extracellular DNA contamination in caput epididymal sperm.

This study shows that small RNAs acquired by sperm in the epididymis are critical for embryonic development in mice, as their absence leads to developmental failure and can be rescued by adding these RNAs.

The paper shows that small RNAs in mature mammalian sperm originate from epididymal somatic cells, not testicular germ cells, and are delivered via vesicular transport during post-testicular maturation.

The paper shows that larval density affects gene expression in C. elegans L1 larvae, identifies a density-dependent gene, and suggests a soluble signaling molecule mediates density sensing.