Adjuvant Delivery Method and Nanoparticle Charge Influence Peptide Amphiphile Micelle Vaccine Bioactivity
Rui Zhang, Brett T Rygelski, Luke E. Kruse, Josiah D. Smith, Xiaofei Wang, Brittany N. Allen, Jake S. Kramer, Gracen F. Seim, Trent J. Faulkner, Huihui Kuang, Efrosini Kokkoli, Adam G. Schrum, Bret D. Ulery
This study investigates how adjuvant delivery methods and nanoparticle charge affect the bioactivity of peptide amphiphile micelle vaccines, showing improved dendritic cell activation with electrostatic complexation.
bioRxiv · Jun 10, 2024 · PreprintBioengineering