Graham Coop

The Strength of Selection Against Neanderthal Introgression

This paper quantifies selection against Neanderthal ancestry in modern humans, finding weak purifying selection likely due to Neanderthal alleles becoming deleterious in larger human populations.

Estimating time to the common ancestor for a beneficial allele

The paper develops a method to estimate the time to the common ancestor of a beneficial allele using a hidden Markov model and applies it to human population data.

A Genealogical Look at Shared Ancestry on the X Chromosome

The paper develops probability distributions for X chromosome IBD segments to infer genealogical relationships and estimate the number of female ancestors between relatives.

A Spatial Framework for Understanding Population Structure and Admixture.

This paper introduces a method to infer geogenetic maps that reflect genetic rather than geographic distances, identifying admixture as anomalous long-distance gene flow.

Convergent Evolution During Local Adaptation to Patchy Landscapes

This paper models how species adapt to patchy environments through convergent evolution or migration, using rock pocket mice as an example to understand genetic signals and adaptation rates.

Adaptation to heavy-metal contaminated environments proceeds via selection on pre-existing genetic variation

The paper shows adaptation to copper-contaminated environments in Mimulus guttatus occurs through selection on pre-existing genetic variation rather than new mutations.

A Coalescent Model of a Sweep from a Uniquely Derived Standing Variant

This paper analyzes a coalescent model of adaptation from a uniquely derived standing variant, showing it is hard to detect and distinguish from other sweep models using genetic polymorphism data.

The role of standing variation in geographic convergent adaptation

This paper investigates how standing genetic variation contributes to convergent adaptation in geographically spread populations, finding that alleles from standing variation play a significant role in adaptation despite potential selective costs.

The Spatial Mixing of Genomes in Secondary Contact Zones

The paper develops a theoretical framework to infer the age of geographic contact zones using population genomic data and applies it to human populations in Indonesia, Central Asia, and India.

Sperm should evolve to make female meiosis fair.

This paper shows that sperm evolve to make female meiosis fair by suppressing meiotic drivers, despite the potential for sperm to collaborate in genomic conflicts.

A Population Genetic Signature of Polygenic Local Adaptation

The paper develops population genetic tests to detect polygenic local adaptation using GWAS data and applies them to the human genome diversity panel to identify putative adaptation signals.

Speciation and introgression between Mimulus nasutus and Mimulus guttatus

This study uses population genomic data to show that Mimulus nasutus diverged from M. guttatus within the last 200-500 thousand years, underwent a shift to selfing, and experiences ongoing introgression with sympatric M. guttatus populations.