Long-range chromatin interactions on the inactive X and at Hox clusters are regulated by the non-canonical SMC protein Smchd1.
Natasha Jansz, Andrew Keniry, Marie Trussart, Heidi Bildsoe, Tamara J Beck, Ian D. Tonks, Arne W. Mould, Peter F. Hickey, Kelsey A. Breslin, Megan Iminitoff, Matthew E. Ritchie, Edwina McGlinn, Graham F. Kay, James M. Murphy, Marnie E. Blewitt
This study identifies Smchd1 as a regulator of long-range chromatin interactions, showing context-dependent effects on transcription and chromatin structure.
bioRxiv · Jun 8, 2018 · PreprintMolecular Biology