Andrew Keniry

SMCHD1's DNA binding activity enables its stable retention on chromatin

This study shows that SMCHD1's weak DNA binding is essential for its chromatin retention and function, revealing how DNA binding affects its localization and gene repression.

SMCHD1 is a novel target for gene-activation therapy to treat Prader-Willi Syndrome

This study identifies SMCHD1 as a target for gene-activation therapy in Prader-Willi Syndrome by showing its role in repressing the PWS gene cluster and demonstrating gene activation in mouse models.

The molecular and cellular anatomy of a fetal programming defect: the impact of low protein diet on the developing kidney.

This study investigates how a maternal low protein diet affects kidney development in mice, revealing molecular and cellular changes that reduce nephron number.

Suv39h-catalysed H3K9me3 is critical for euchromatic genome organisation and the maintenance of gene transcription

This study shows that Suv39h enzymes are essential for organizing euchromatic regions and maintaining gene transcription by tethering H3K9me3 domains to the nuclear lamina.

SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease

This study identifies a mutation in SMCHD1 that enhances gene silencing and disrupts developmental processes, revealing distinct roles of SMCHD1 in chromatin structure and gene regulation.

Maternal SMCHD1 regulates Hox gene expression andpatterning in the mouse embryo

This study shows maternal SMCHD1 prevents premature Hox gene activation in mouse embryos, leading to posterior homeotic transformations when absent.

Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation

This study shows maternal SMCHD1 is essential for imprinted Xist expression and X chromosome inactivation in mouse embryos and placenta.

Smchd1 is a maternal effect gene required for autosomal imprinting

This study identifies Smchd1 as a maternal effect gene that regulates imprinted expression of 16 genes by translating polycomb-mediated histone methylation marks into a heritable chromatin state.

Using long-read sequencing to detect imprinted DNA methylation

The paper uses long-read nanopore sequencing to detect imprinted DNA methylation and identifies known and novel differentially methylated regions.

Long-range chromatin interactions on the inactive X and at Hox clusters are regulated by the non-canonical SMC protein Smchd1.

This study identifies Smchd1 as a regulator of long-range chromatin interactions, showing context-dependent effects on transcription and chromatin structure.